Lopunny

Lopunny is as cute as it is useless in Pokémon GO; its Attack stat is way too low, and its mediocre movepool and bulk don’t help either. Its Mega Evolution isn't terrible though, having a good Attack stat and STAB on its Fighting-type attacks.

Best PvE Offensive Moveset

• Double Kick pairs with Focus Blast to fulfill a Fighting-type role, though actual Fighting-type Pokemon are better. Consider Mega Evolving it.

• Pound gets STAB but can't be Super Effective against anything. 

• Fire Punch allows some extra chip damage right before Lopunny faints. 

• Despite STAB, Hyper Beam isn’t really useful on offense.

Best PvE Defensive Moveset

• Double Kick performs the best on defense with its higher base power, and has a chance to be Super Effective. 
• Low Kick is a direct downgrade. 
• Pound is neutral at best and resisted at worst. 
• Fire Punch and Triple Axel are the only charged moves that Lopunny could be able to use before getting steamrolled.
• Focus Blast and Hyper Beam are way too slow for defense. 

Double Kick offers high energy generation, allowing Lopunny to access its Charge Moves sooner. Pound and Low Kick are terrible. 

Fire Punch offers more consistent damage with its moderately low energy cost, and helps to bait shields. Triple Axel has great coverage and a self-buffing effect for Attack, but its power is fairly low. Focus Blast hits hard and provides useful coverage, but its massive energy cost is very discouraging. Hyper Beam is an alternative that offers powerful neutral damage with STAB, if it doesn't go unshielded.