Nidoqueen

Nidoqueen is the defensive half of the Nido-royalty. Unfortunately, Nidoqueen’s stats aren’t very defensive, and weaknesses to the common Psychic and Water types only hurt. There’s little point to using Nidoqueen on offense when Nidoking has the same optimal movesets and 24 more points of Atk.

Best PvE Offensive Moveset

• Poison Jab and Bite are similar in a vacuum, but Poison Jab has type synergy with Sludge Wave.

• Sludge Wave is Nidoqueen’s best charge move. It has limited but unique Poison-type coverage with STAB.

• Poison Fang doesn't deal enough damage to be useful for PvE offense. 

• Earth Power performs better than Earthquake, but doesn’t pair well with Nidoqueen’s fast moves even STAB.

• Without STAB, Stone Edge is poor on offense.

Best PvE Defensive Moveset

• Poison Jab has double the power of Bite when factoring in STAB.

• Poison Fang can be used frequently as a 3-bar move, but isn't particularly strong. 

• Stone Edge has an early damage window, but it takes a lot of energy to reach it.

• Earth Power is decent as a 2-bar option, but it has a late damage window. 

• Sludge Wave and Earthquake, though both have STAB, are easily resisted or reacted to.

Poison Jab is the fast move of choice due to STAB and much higher energy gains. Bite deals strong Dark-type damage, but lacks STAB and energy gains. 

Poison Fang is all but mandatory on Nidoqueen, functioning as both a strong bait move and a powerful spammy option in its own right. Earth Power helps Nidoqueen access a Ground-type charge move sooner, while Stone Edge provides wide coverage. Since both Earth Power and Stone Edge cost the same energy, Nidoqueen doesn't need to shield bait. Sludge Wave or Earthquake could be chosen as harder-hitting options, but the cost of 10 more energy risks Nidoqueen fainting before being able to use them.